This Stieg Larsson thing is going nuts — who knew this would be the "hottest book on the planet"? And how often do you see a book on the cover of EW? Pretty good article, though the main emphasis seems to be on speculation about the casting of the upcoming Hollywood version of TGWTDT.
My vote? Brad Pitt for Blomkvist, old enough yet still a believable babe magnet and an actor with a great range; for Lisbeth Salander, I tend to agree with Roger Ebert that they should just hire Noomi Rapace to do it in English, but I know she's done with that role.
Who will it be? Someone less than 6 feet tall and 200 pounds, and not with a cute round face like some of the possibles being mentioned. Do it right, people, choose an unknown with the right edge!